Colorectal Cancer

Colorectal cancer spans colon and rectal disease, often engaging WNT/APC, RAS/RAF/MAPK, PI3K, and mismatch-repair (MMR) biology; MSI-H/dMMR links tightly to immunotherapy response. We provide biomarker antibodies (CEA/CA19-9) and readout tools across EGFR, VEGF, and DNA-damage repair for resistance and combination studies.

Focus areas: MSI/MMR & immune milieu, RAS/BRAF stratification & anti-EGFR rules, liver metastasis & angiogenesis, neoadjuvant/perioperative biomarkers

Colorectal cancer–related antibodies (curated)

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Hot topics & directions

  • MSI-H / dMMR & immunotherapy: PD-(L)1 response vs TMB/neoantigen presentation readouts.
  • RAS/BRAF status & anti-EGFR: Primary resistance vs MAPK/PI3K bypass—paired specimen design.
  • Liver metastasis niche: Angiogenesis, fibrosis, and immunosuppressive myeloid coupling.
  • Neoadjuvant regression: Pathologic regression scoring vs serial circulating markers.

Related targets

WNT / APC axis
APC, CTNNB1 (β-catenin), AXIN1/2, TCF7L2
RAS / RAF / MAPK
KRAS, NRAS, BRAF, MAPK1/3 (ERK1/2), MAP2K1/2
Growth & angiogenesis
EGFR, ERBB2, MET, VEGFA, KDR (VEGFR2)
MMR / checkpoints
MLH1, MSH2, MSH6, PMS2, CD274 (PD-L1), PDCD1 (PD-1)

Key signaling pathways

  1. WNT–APC–β-catenin
    Early adenoma–carcinoma drivers; intestinal stem niche coupling.
  2. MAPK stress output
    RAS/RAF lesions amplify proliferation/survival; gate anti-EGFR use.
  3. PI3K–AKT–mTOR
    Anabolic programs; RTK feedback shapes resistance.
  4. VEGF/血管生成
    Angiogenesis, vessel normalization, hypoxic phenotypes.

Tool compounds (research use)

Commonly used for mechanistic studies; follow your lab SOP, compound datasheets, and ethics approvals.

CompoundTargets / pathwaysExperimental notes
Cetuximab (anti-EGFR mAb)EGFR (blockade)Most used in RAS-wildtype contexts; monitor rash and bypass activation.
Bevacizumab (anti-VEGF mAb)VEGF-AAngiogenesis axis probe; mind BP/wound healing in vivo.
RegorafenibMulti-kinase (VEGFR/KIT/RET/RAF, etc.)Common in refractory models; dose-window and off-target controls.
TrametinibMEK1/2MAPK probe in BRAF-mutant settings; watch RTK feedback.
5-FluorouracilTS / DNA synthesis (context-dependent)Classic backbone; pair with MMR/replication-stress time courses.
OxaliplatinDNA crosslink / replication stressICD-related readouts; often paired with DDR markers (γH2AX).
VeliparibPARP1/2Replication stress/BRCAness exploration; matrix DDR toxicities.