Epigenetics

Epigenetics studies heritable regulation without changing DNA sequence: DNA methylation, histone PTMs, chromatin remodeling, and non-coding RNAs. We provide histone PTM antibodies, methylation/demethylation & acetylation readout tools, and chemical probes (HDAC, EZH2, BET, etc.) linking chromatin states to transcriptional control.

Focus areas: activating vs repressive marks & enhancer logic, DNA methylation & TET oxidation, PRC2 silencing domains, SWI/SNF-driven accessibility

Epigenetics-related antibodies (curated)

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Hot topics & directions

  • Histone code & phase separation: Coupling writers/erasers/readers to transcriptional condensates.
  • DNA methylation dynamics: Maintenance vs de novo DNMTs and TET oxidation shaping enhancers/silencing borders.
  • PRC2 & developmental plasticity: Competitive remodeling of H3K27me3 domains during fate transitions.
  • Accessibility & disease: Integrating ATAC/CUT&RUN with SWI/SNF mutations and enhancer rewiring.

Related targets

Histone writers/erasers (examples)
EZH2, NSD1/2/3, DOT1L, KMT2A/MLL, KDM5A/JARID1, HDAC1–11 classes, KAT2A/EP300
Reader modules
BRD2/3/4, YEATS, Tudor, PHD finger proteins (context-dependent)
DNA methylation machinery
DNMT1, DNMT3A/B, UHRF1, TET1/2/3, TDG (repair coupling)
Remodeling complexes
SMARCA4/ARID1A (BAF), CHD, INO80 (system-dependent)

Target gene symbols (clickable)

Histone-modifying enzymes (e.g. EZH2) link to the histone-modifying hub; DNA methylation and remodeling modules below.

DNA methylation

DNA methylation & active demethylation

DNMT1, DNMT3A, DNMT3B, DNMT3L, UHRF1, TET1, TET2, TET3, TDG, MBD4

Chromatin remodeling

Chromatin remodeling complexes

SMARCA4, SMARCA2, ARID1A, ARID1B, ARID2, SMARCB1, SMARCE1, CHD4, CHD3, CHD1, INO80, SRCAP

Polycomb

Polycomb (writers/readers)

Histone enzyme pages (e.g. EZH2) live on the histone-modifying hub.

EZH2, SUZ12, EED, RING1, BMI1, CBX2, CBX4, CBX7

Topology & structure

Topology & structural proteins

CTCF, RAD21, SMC1A, SMC3, STAG1, STAG2, YEATS2, YEATS4

Key signaling pathways

  1. Polycomb: PRC2 (EZH2) → H3K27me3 vs PRC1 → H2AK119ub
    Layered Polycomb loops establish and maintain silencing domains.
  2. HAT/HDAC balance ↔ enhancer acetylation
    p300/CBP vs HDAC competition shapes enhancer acetylation and BRD readout.
  3. TET–TDG–BER coupling (active demethylation)
    Oxidized methylcytosine intermediates coupled to repair—separate passive dilution vs active demethylation.
  4. SWI/SNF–CTCF–cohesin topology
    Epigenetic basis of TADs and E–P looping.

Tool compounds (research use)

Commonly used for mechanistic studies; follow your lab SOP, compound datasheets, and ethics approvals.

CompoundTargets / pathwaysExperimental notes
Vorinostat (SAHA)HDAC (pan; class-dependent at concentration)Common for acetylome/expression readouts; cytotoxicity & isoform selectivity vary.
Trichostatin A (TSA)HDAC (classic tool)Potent in vitro; light-sensitive—storage and vehicle controls matter.
MS-275 (Entinostat)HDAC1/3-biased (interpret cautiously)Often used as a more “in vivo–tolerable” HDACi comparator—validate selectivity.
GSK126EZH2 methyltransferase activityH3K27me3 inhibition readouts; separate catalytic vs scaffolding/compensation.
UNC0638G9a / GLP (H3K9 methyltransferases)Heterochromatin/silencing; cross-talk with DNMT axis and off-targets.
JQ1BET bromodomains (BRD2/3/4, etc.)Super-enhancer/transcriptional condensates; validate paralog selectivity.
DecitabineDNMTs (DNA incorporation)Hypomethylation with replication coupling; manage cytotoxicity per SOP/ethics.