Ubiquitination

Ubiquitination is a deeply conserved PTM that not only marks proteolytic substrates but also rewires signaling, DNA-damage responses, immune-receptor regulation, and chromatin states. We provide antibodies and chemical tools spanning Ub, E3 ligases, and DUBs—from linkage-specific recognition to E3–substrate engagement and PROTAC design.

Focus areas: linkage-encoded signaling (K48/K63/linear, etc.), E3 substrate recognition & phospho-coupling, DUB editing & signal termination, CRL/NEDD8 dynamics

Ubiquitination-related antibodies (curated)

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Hot topics & directions

  • Ub chain topology & signaling semantics: How K63/K11/M1-linear chains partition receptor signaling vs immunity.
  • E3 substrate recognition & allostery: Phosphodegrons, molecular recognition, vs PROTAC-induced neointeractions.
  • DUB editing & signal reset: Is deubiquitination reversal—or reshaping chain type and receptor fate?
  • DNA damage & repair pathways: RNF168/BRCA1-like E3/DUB networks coupling repair foci to chromatin access.

Related targets

E1–E2–E3 modules (examples)
UBA1, UBE2D family, UBE2N/UBE2V1, BRCA1/BARD1, RNF8/RNF168, MDM2, HUWE1
DUB families (examples)
USP7/USP10, OTUB1, CYLD, A20/TNFAIP3, ATXN3, VCPIP1
Linkages & readers
K48/K63/K11/M1-specific binders, NZF/UBZ/UIM motifs (protein context)
Ubl cross-talk
NEDD8–cullin, SUMOylation, ISG15 (interferon contexts; model-dependent)

Key signaling pathways

  1. SCFβ-TrCP–IκB–NF-κB
    Phosphodegrons toggle signal termination vs inflammatory amplification.
  2. MDM2–p53–Ub feedback
    Classic DDR/fate loop; DUBs (e.g., USP7) edit the network.
  3. K63-linked Ub in immune signaling
    Scaffold/adaptor roles often non-proteolytic—separate from K48 branches.
  4. CRL cycles: neddylation → substrate ubiquitylation → deneddylation
    CSN complex + NAE inhibitors help time CRL activity windows.

Tool compounds (research use)

Commonly used for mechanistic studies; follow your lab SOP, compound datasheets, and ethics approvals.

CompoundTargets / pathwaysExperimental notes
PYR-41UBA1 (E1 activating enzyme)Blocks upstream Ub activation; cytotoxic/off-target—use dose/time matrices.
MLN4924 (Pevonedistat)NAE1 / NEDDylation (CRL axis)Common for CRL turnover/substrate accumulation; pair cell-cycle readouts.
P5091USP7DUB tool; intersects MDM2–p53/DDR—mind substrate spectrum.
PR-619Broad-spectrum DUB inhibitionCoarse DUB-dependency screens; follow with selective inhibitors or genetics.
MG132ProteasomeUb-substrate accumulation vs turnover block; mind non-specific stress.
LactacystinProteasome (irreversible tool)Often paired vs MG132; cytotoxic—window doses.
LenalidomideCRBN (IMiD / molecular-glue context)CRBN substrate recruitment/degradation contexts; species/cell-line dependent.