PI3K/Akt/mTOR · target hub
Phosphoinositide 3-kinase regulatory subunit 4 (VPS15-like adaptor)
PIK3R4 encodes a key regulatory/scaffold partner for the class III PI3K holoenzyme with PIK3C3/VPS34, coupling endosomal trafficking and vesicle dynamics to programs that intersect autophagy initiation; it cross-talks with class I PI3K–Akt–mTOR signaling across membrane compartments—do not equate class III PI3K with canonical PIP2→PIP3 nutrient signaling when interpreting Akt/mTOR readouts.
| Type / example | Domain / context (brief) |
|---|---|
| Expression context | Tissue/cell-type–dependent expression |
| Rare variants | Sporadic variants—require functional validation |
| Pathway coupling | Co-occurs with neighboring nodes on the hub |
Naming and prevalence vary by cohort and assay—annotate clinically with COSMIC, ClinVar, OncoKB, and datasheets; research context only.
Examples below reflect common literature and public resources (e.g., CCLE, DepMap)—validate genotypes, expression, and passage in your own stocks before committing assays.
Human tissues and primary cells require ethics/IRB approval; tumors are heterogeneous—record histotype, site, and preservation conditions.
Overexpression vs endogenous PIK3R4 can differ in dosage, splicing, and compartmentation—in organoids/PDX, record passage, matrix, and drug history.
Adds PIK3R4 keyword bias atop the PI3K/Akt/mTOR antibody pool—if sparse, use presets above or global search.
This content supports research reagents and pathway education—not medical advice. Annotate mutations, drug indications, and protocols with authoritative databases, datasheets, and institutional oversight.
Last reviewed: 2026-05-18
See the PI3K/Akt/mTOR hub for neighboring nodes and assay guidance—cross-check MAPK, RTK, metabolism, and autophagy pages as needed.